Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality.

doi:10.1016/j.bmc.2015.08.027

Paper

Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality.

Published Oct 1, 2015 · D. Raffa, B. Maggio, F. Plescia

Bioorganic & medicinal chemistry

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13

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0

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Abstract

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In Vitro Study

Study Snapshot

Novel 2-phenoxyacetamidobenzamides show antiproliferative activity against various cancer cell lines, with the most active compounds inducing apoptosis through caspase activation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality.

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