Synthesis and antiviral activity of N-aryl- and N-heterylsuccinamic acids and their salts with 2-amino-2-thiazoline

doi:10.1007/BF02223742

Paper

Synthesis and antiviral activity of N-aryl- and N-heterylsuccinamic acids and their salts with 2-amino-2-thiazoline

Published Nov 1, 1996 · D. Burdulene, Z. Stumbryavichyute, Z. Talaikite

Pharmaceutical Chemistry Journal

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4

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0

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Abstract

I Institute of Biochemistry, Vilnius, Lithuania. 2 Research Institute of Epidemiology and Microbiology, Minsk, Belarus. cinic acid with N-(4-antipyryl) groups and studied their antiviral properties [2, 3]. The purpose of this work was to search for new antiviral drugs in the series of succinamic acids. In order to obtain water-soluble compounds, the succinamic acids were converted into salts with 2-amino-2-thiazoline (AT).

Study Snapshot

N-aryl- and N-heterylsuccinamic acids and their salts with 2-amino-2-thiazoline show promising antiviral activity against various viruses.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and antiviral activity of N-aryl- and N-heterylsuccinamic acids and their salts with 2-amino-2-thiazoline

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References

Citations

Investigation of supramolecular synthons in the crystals of N-(aryl)-succinamic acids and N-(aryl)-maleamic acids: A case study of 4-oxo-4-(pyridin-2-ylamino)butanoic acid

The crystal structure of 4-oxo-4-(pyridin-2-ylamino)butanoic acid reveals a unique supramolecular synthon structure, with a unique 1D architecture and a different repetitive supramolecular synthon than previously reported.

Synthesis, crystal & molecular structure studies and Hirshfeld surface analysis of 4-oxo-4-(pyridin-3-ylamino)butanoic acid

4-oxo-4-(pyridin-3-ylamino)butanoic acid has a unique molecular and crystal structure, with strong hydrogen bonds and C H-O interactions resulting in a two-dimensional (2D) zig-zag sheet and a three-dimensional (3D) supra

Synthesis and Antitumor Activity of Substituted Succinamides Using a Potato Disc Tumor Induction Assay

Novel succinic acid derivatives show potential as antitumor agents, with compound 7b showing the highest activity, -80.50% tumor inhibition compared to vincristine.