Paper

Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems.

Published Nov 1, 2016 · A. Waszkielewicz, M. Kubacka, K. Pańczyk

Bioorganic & medicinal chemistry letters

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Abstract

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Non-RCTAnimal Study

Study Snapshot

New piperazine derivatives show potential as new hypotensive agents and antidepressant-like agents, with compound 3 showing selective 1 receptor antagonistic properties and reducing blood pressure by 10-13% in rats.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems.

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