Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems.

doi:10.1016/j.bmcl.2016.09.037

Paper

Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems.

Published Nov 1, 2016 · A. Waszkielewicz, M. Kubacka, K. Pańczyk

Bioorganic & medicinal chemistry letters

Q2 SJR score

8

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

New piperazine derivatives show potential as new hypotensive agents and antidepressant-like agents, with compound 3 showing selective 1 receptor antagonistic properties and reducing blood pressure by 10-13% in rats.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Synthesis and activity of newly designed aroxyalkyl or aroxyethoxyethyl derivatives of piperazine on the cardiovascular and the central nervous systems.

Sign up to use Study Snapshot

References

Citations

Advances in drug design and therapeutic potential of selective or multitarget 5-HT1A receptor ligands.

Selective or multitarget 5-HT1A receptor ligands show potential for treating complex psychiatric and neurodegenerative disorders.

The Subtype Selectivity in Search of Potent Hypotensive Agents among 5,5-Dimethylhydantoin Derived α1-Adrenoceptors Antagonists

5,5-dimethylhydantoin derivatives show high activity and selectivity towards 1-adrenergic receptors, with the most active compound (5) showing a lower effective dose than urapidil and a stronger effect than prazosin.

Green chemistry approach towards Piperazine: anticancer agents

Green chemistry methods can effectively synthesize piperazine analogues, offering sustainable anticancer drug development with improved therapeutic efficacy.

DABCO bond cleavage for the synthesis of piperazine derivatives

DABCO bond cleavage is an efficient strategy for the synthesis of diverse drug-like piperazine derivatives in synthetic organic chemistry.

Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system.

Di- or trisubstituted N-(phenoxyalkyl)- or N-2-[2-(phenoxy)ethoxy]ethyl-piperazine derivatives show anxiolytic, anticonvulsant, and analgesic activity in mice, with potential applications in

Synthesis and biological evaluation of N-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2H,4H)-dione as potential antiplatelet agents

N-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2H,4H)-dione show potential as novel antiplatelet agents with an alternative mechanism of action.

Spectroscopic (FT-IR, FT-Raman, UV, NMR, NLO) investigation, molecular docking and molecular simulation dynamics on 1-Methyl-3-Phenylpiperazine

1-Methyl-3-Phenylpiperazine shows potential inhibitory activity against Clostridium botulinum (2J3X) and its structure suggests potential for pharmaceutical applications.