Synthesis and anticonvulsant activity of new N-Mannich bases derived from 3-(2-fluorophenyl)- and 3-(2-bromophenyl)-pyrrolidine-2,5-diones. Part II.

doi:10.1016/j.bmc.2012.05.032

Paper

DOI: 10.1016/j.bmc.2012.05.032

Synthesis and anticonvulsant activity of new N-Mannich bases derived from 3-(2-fluorophenyl)- and 3-(2-bromophenyl)-pyrrolidine-2,5-diones. Part II.

Published Aug 1, 2012 · J. Obniska, S. Rzepka, K. Kamiński

Bioorganic & medicinal chemistry

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

New N-Mannich bases derived from 3-(2-fluorophenyl)- and 3-(2-bromophenyl)-pyrrolidine-2,5-diones show more potent and less neurotoxic anticonvulsant activity than phenytoin.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1016/j.eplepsyres.2011.08.016

Ligand based pharmacophore model development for the identification of novel antiepileptic compound

This study developed a ligand-based pharmacophore approach to identify novel antiepileptic compounds with improved efficacy and tolerability using LigandScout software and distance estimation.

2012·37citations·H. Khan et al.·Epilepsy Research

Epilepsy Research

DOI: 10.1016/j.bmcl.2011.07.118

Synthesis and anticonvulsant activity of new 1-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrrolidine-2,5-diones.

New 1-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrrolidine-2,5-diones show high anticonvulsant activity in various seizure models, with the most active compounds showing high activity in the 6-Hz psychomotor seizu

2011·40citations·K. Kamiński et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

DOI: 10.1016/j.ejmech.2011.07.043

Synthesis and anticonvulsant properties of new acetamide derivatives of phthalimide, and its saturated cyclohexane and norbornene analogs.

New piperazine or morpholine acetamides show promising anticonvulsant properties, with the most active compound being 2-2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethyl-isoindoline-1

2011·45citations·K. Kamiński et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1016/j.seizure.2011.01.003

Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs

Current animal models for seizures and epilepsy may not identify all potential antiepileptic drugs, and a shift in preclinical strategies is needed to identify therapies more effective in refractory populations and lead to cures.

2011·801citations·W. Löscher·Seizure

Seizure

DOI: 10.1016/j.bmc.2010.06.064

Design, synthesis, and anticonvulsant activity of new N-Mannich bases derived from spirosuccinimides and spirohydantoins.

New N-Mannich bases derived from spirosuccinimides and spirohydantoins show promising anticonvulsant properties, with several showing greater potency than phenytoin.

2010·45citations·J. Obniska et al.·Bioorganic & medicinal chemistry

Bioorganic & medicinal chemistry

Citations

DOI: 10.1016/j.molstruc.2024.141248

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This study presents a Rh(III)-catalyzed 1,4-addition method for synthesizing ortho-alkylated succinimide derivatives, which show superior anti-inflammatory and anti-diabetic activities compared to standard drugs.

2024·0citations·Pakkirisamy Sivakumar et al.·Journal of Molecular Structure

Journal of Molecular Structure

DOI: 10.1016/J.CDC.2021.100770

An efficient synthesis and characterization of novel (Z)-1-phenyl(arylamino)methylpyrrolidine-2,5-dione derivatives as potential analgesic agents

Novel (Z)-1-phenyl(arylamino)methylpyrrolidine-2,5-dione derivatives show potential as analgesic agents, with good yields and confirmed structures.

2021·3citations·Y. Trukhanova et al.·Chemical Data Collections

Chemical Data Collections

DOI: 10.1016/j.ejps.2020.105494

Recent advancement in the discovery and development of anti-epileptic biomolecules: An insight into structure activity relationship and Docking.

Recent advances in anti-epileptic drug discovery focus on structure-activity relationships, docking studies, and their mechanism of actions to potentially reduce or cure epilepsy.

2020·6citations·Mukund Jha et al.·European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

DOI: 10.1016/j.bmcl.2019.06.001

Synthesis and pharmacological evaluation of novel N-Mannich bases derived from 5,5-diphenyl and 5,5-di(propan-2-yl)imidazolidine-2,4-dione core.

Novel N-Mannich bases with imidazolidine-2,4-dione core show potential as a reduced toxicity and broad anticonvulsant with potential benefits in treating chronic pain.

2019·2citations·A. Czopek et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

DOI: 10.1016/J.MOLSTRUC.2018.12.083

Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives

Novel succinimide derivatives synthesized using microwave irradiation show promising antifungal activities, with 1-(4-Bromophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione showing potential as a novel fungicide.

2019·12citations·J. Cvetkovic et al.·Journal of Molecular Structure

Journal of Molecular Structure