Synthesis and biological activity of novel 2-thiazolidiones sulfonylurea derivatives

Paper

Synthesis and biological activity of novel 2-thiazolidiones sulfonylurea derivatives

Published 2008 · Shen De-long

Journal of Zhejiang University of Technology

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Abstract

The sulfonylurea herbicides are a kind of weed control agents characterized by broad-spectrum,ultralow dosage,good crop selectivity and low mammalian toxicity.2-Thiazolidiones can be used directly as fungicide,insecticide and plant growth regulator.The phototoxicity of sulfonylurea herbicides residues to succeeding crops has become one of important factors affecting its further development.In order to search for some new lead compounds,using 2-thiazolidiones,mono-substituent benzenesulfonamide and oxalyl chloride as starting materials,five new derivatives were synthesized from isocynate.The structures of these compounds were confirmed by NMR,IR,MS.Preliminary bioassays indicated that all compounds possessed no fungicidal and insecticidal activity.Only one new compound exhibited good herbicidal activity.The inhibition rate was 91.1% at 100 mg/L against the root of Echinochloa Crusgalli.

Study Snapshot

Novel 2-thiazolidiones sulfonylurea derivatives show potential as weed control agents, but their fungicidal and insecticidal activities are limited.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and biological activity of novel 2-thiazolidiones sulfonylurea derivatives

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References

Citations

Synthesis of 2-Acyloxycyclohexylsulfonamides and Evaluation on Their Fungicidal Activity

Compound III-18 shows high fungicidal activity against Botrytis cinerea, with better control than commercial fungicide procymidone and broader fungicidal spectra than chlorothalonil.