Synthesis, antibacterial activity and QSAR studies of 1,2-disubstituted-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines.

doi:10.1016/J.EJMECH.2005.10.010

Paper

Synthesis, antibacterial activity and QSAR studies of 1,2-disubstituted-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines.

Published Jul 4, 2006 · R. Tiwari, Devender Singh, Jaspal Singh

European journal of medicinal chemistry

Q2 SJR score

50

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1

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Abstract

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In Vitro Study

Study Snapshot

1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 4a-c shows promising antibacterial activity against standard Gram positive and Gram negative bacteria, with a MIC 3.5-20 microg ml(-1) and a positive QSAR study.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis, antibacterial activity and QSAR studies of 1,2-disubstituted-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines.

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