Synthesis and fungicidal activity against Rhizoctonia solani of 2-alkyl (Alkylthio)-5-pyrazolyl-1,3,4-oxadiazoles (Thiadiazoles).

doi:10.1021/JF991065S

Paper

Synthesis and fungicidal activity against Rhizoctonia solani of 2-alkyl (Alkylthio)-5-pyrazolyl-1,3,4-oxadiazoles (Thiadiazoles).

Published Oct 21, 2000 · H. Chen, Z. Li, Y. Han

Journal of agricultural and food chemistry

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225

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Abstract

Some series of 2-alkyl (alkythio)-5-((4-chloro)-3-ethyl-1-methyl-1H-pyrazole-5-yl)-1,3, 4-oxadiazoles (thiadiazoles) were prepared as potential fungicides. Their fungicidal activity was evaluated against rice sheath blight, which is a major disease of rice in China. Structure-activity relationships for the screened compounds were evaluated and discussed. It was found that 5-(4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-yl)-1,3, 4-thiadiazole-2-thione has the higher fungicidal activity.

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Study Snapshot

5-(4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-yl)-1,3,4-thiadiazole-2-thione shows the highest fungicidal activity against rice sheath blight, a major disease in China.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and fungicidal activity against Rhizoctonia solani of 2-alkyl (Alkylthio)-5-pyrazolyl-1,3,4-oxadiazoles (Thiadiazoles).

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References

Citations

Copper-Catalyzed Oxidative Synthesis of 3-Aryl-5-fluoroalkyl-1,3,4-oxadiazol-2(3H)-ones Using Perfluorocarboxylic Anhydride as a Reagent.

Copper-catalyzed oxidative synthesis of 3-aryl-5-fluoroalkyl-1,3,4-oxadiazol-2(3H)-ones with perfluorocarboxylic anhydride provides high yields and demonstrates synthetic utility.

Exploring target site interactions of 1,3,4-Oxadiazole/1,3,4-thiadiazole derivatives: Synthesis, characterization in vitro anti-urease and in silico molecular docking studies

1,3,4-oxadiazole and 1,3,4-thiadiazole hybrid derivatives show promising potential as potent anti-urease agents, with analogue 11 and 14 showing excellent inhibitory potential compared to thiourea.

N-arylpyrazole based Scaffolds: Synthesis and biological applications

N-arylpyrazole derivatives show potential in various biological activities, including antibiotics, antifungals, and anticoagulants, with various synthesis protocols and applications.

Urease inhibitory potential of pyridine-containing triazolothiadiazole and triazolothiadiazine scaffolds for the treatment of ulceration and kidney stone: in vitro screening, kinetics mechanism, and in silico computational analysis.

Triazolothiadiazole and triazolothiadiazine scaffolds show potential as antiurease agents, with compounds 4e and 6e showing the highest inhibitory potential, potentially reducing the risk of urinary calculi and ulceration.

In silico and in vitro evaluation of newly synthesized pyrazolo-pyridine fused tetrazolo-pyrimidines derivatives as potential anticancer and antimicrobial agents.

Newly synthesized pyrazolo-pyridine fused tetrazolo-pyrimidines show potential as anticancer and antimicrobial agents, with 10ah showing the highest potency against MCF-7 cells and 10bc and 10bh showing excellent cytotoxicity against HEK-2

Transition-metal-free direct arylselenation of 1-aryl-3-Methyl pyrazolones using diselenides

The novel approach using diselenides efficiently produces diverse pharmacologically active 4-(organylselenyl) pyrazolones under transition-metal-free conditions.

Microwave-Assisted Synthesis of Unsymmetrical 5-Phenyl-1,3,4-oxadiazoles Containing Bis(carboxymethyl)amino Group

Microwave-assisted cyclodehydration of unsymmetrical N,N′-diacylhydrazines leads to the synthesis of 5-phenyl-1,3,4-oxadiazoles with bis(carboxymethyl)amino groups in satisfactory yields.