Paper

Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies.

Published Jan 5, 2017 · V. Semenov, B. Lichitsky, A. Komogortsev

European journal of medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

The synthesized dihydroisothiazolopyridinones show significant antimitotic microtubule destabilizing activity, potentially targeting cancer cells and chemoresistant cell lines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies.

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