Paper

Synthesis and anticonvulsant activity of trans- and cis-2-(2,6-dimethylphenoxy)-N-(2- or 4-hydroxycyclohexyl)acetamides and their amine analogs.

Published Nov 15, 2011 · E. Pękala, A. Waszkielewicz, E. Szneler

Bioorganic & medicinal chemistry

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Abstract

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Non-RCTAnimal Study

Study Snapshot

Racemic trans-2-(2,6-dimethylphenoxy)-N-(2-hydroxycyclohexyl)acetamide effectively reduces seizures and raises seizure threshold, mainly through inhibition of voltage-gated sodium currents and enhancement of GABA effect.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and anticonvulsant activity of trans- and cis-2-(2,6-dimethylphenoxy)-N-(2- or 4-hydroxycyclohexyl)acetamides and their amine analogs.

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