Synthesis and antidepressive activity of 3-methyl-5-phenyl-2-(3-fluorophenyl)morpholine hydrochloride

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Synthesis and antidepressive activity of 3-methyl-5-phenyl-2-(3-fluorophenyl)morpholine hydrochloride

Published 2012 · Tao Yuan

Applied Chemical Industry

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Abstract

3-Methyl-5-phenyl-2-(3-fluorophenyl)morpholine hydrochloride was synthesized from 2-bromo-1-(3-fluorophenyl)-1-propanone via aminnation and cyclization in nonproton polar solvent,at last acidified by divergent synthetic method,with yield of 70.6%.Its structure was confirmed by IR and 1H NMR.Their antidepressant activities were tested with mice forced swimming test.The compound is worth to the further investigate in antidepressant activity.

Study Snapshot

3-Methyl-5-phenyl-2-(3-fluorophenyl)morpholine hydrochloride shows promising antidepressive activity, warranting further investigation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and antidepressive activity of 3-methyl-5-phenyl-2-(3-fluorophenyl)morpholine hydrochloride

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