Chemical-enzymic synthesis and conformational analysis of sialyl Lewis X and derivatives

doi:10.1021/JA00050A007

Paper

Chemical-enzymic synthesis and conformational analysis of sialyl Lewis X and derivatives

Published Nov 1, 1992 · Y. Ichikawa, Ying-Chih Lin, D. P. Dumas

Journal of the American Chemical Society

Q1 SJR score

267

Citations

2

Influential Citations

Full textSemantic Scholar

Abstract

Sialyl Lewis x and derivatives have been synthesized using β-1,4-galactosyltransferase and recombinant α-2,3-sialyltransferase and α-1,3-fucosyltransferase. The enzymatic glycosylations have been achieved on preparative scales with in situ regeneration of UDP-galactose, CMP-N-acetylneuraminic acid, and GDP-fucose. Additionally, galactosyltransferase and fucosyltransferases have been studied with respect to their substrate specificity and inhibition

Highly Cited

Study Snapshot

Sialyl Lewis X and derivatives can be synthesized using enzymatic glycosylation, enabling their potential use in pharmaceuticals and biosensors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Chemical-enzymic synthesis and conformational analysis of sialyl Lewis X and derivatives

Sign up to use Study Snapshot

References

Citations

Sialyl Lewis X (sLex):Biological functions, synthetic methods and therapeutic implications.

Sialyl Lewis X (sLex) plays a crucial role in various biological processes, including cell adhesion, immune response, and cancer metastasis, with potential impact on clinical practice.

Efficient derivatization-free monitoring of glycosyltransferase reactions via flow injection analysis-mass spectrometry for rapid sugar analytics

Flow injection analysis-mass spectrometry (FIA-MS) provides rapid, accurate data for real-time monitoring of enzyme reactions, enabling efficient process control and glycan synthesis.

Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins

Sialyl Lewis X (sLeX) plays a crucial role in various biological processes, such as fertilization and immune response, and its synthesis and detection methods have attracted significant research attention.

Recent progress on health effects and biosynthesis of two key sialylated human milk oligosaccharides, 3'-sialyllactose and 6'-sialyllactose.

Sialylated human milk oligosaccharides (3'-SL) and (6'-SL) show promising prebiotic effects, promoting gut health and brain development in infants, and can be biosynthesised using enzymatic and microbial approaches.

Iminosugars as glycosyltransferase inhibitors.

Iminosugars show potential as inhibitors of glycosyltransferases, potentially leading to innovative therapeutic agents for cancer and bacterial infections.

Synthetic Carbohydrate Chemistry and Translational Medicine.

New glycoscience methodologies and tools have advanced our understanding of glycosylation and its relevance in disease progression and immune-response signaling, leading to the development of carbohydrate-derived medicines.