Paper
Synthesis and Antibacterial Activities of Some Indolizine Carboxylic Acids
Published 2012 · Jiang Yu
Chemical Journal of Chinese Universities-chinese
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Abstract
A new procedure for the synthesis of indolizine carboxylic acids were developed.In the presence of tetrakispyridinecobalt(Ⅱ) dichromate(TPCD),indolizine carboxylic acid esters were readily synthesized by a one-pot reaction sequence which consists of a 1,3-dipolar cycloaddition of pyridinium N-ylides to alkenes,followed by an aromatization.Eigth indolizine carboxylic acids 3a—3c and 5a—5e were obtained in good yields by the direct hydrolysis of the crude indolizine carboxylic acid esters,and characterized by IR,1H NMR,MS and elemental analysis.The study on the antibacterial activity of these compounds against escherichia coli and staphylococcus aureus indicated that compounds 3a,3c,5a,5c and 5d had a certain inhibitory effect on escherichia coli,while compounds 3a and 3c showed some inhibitory effect on staphylococcus aureus.Compound 3c showed good antimicrobial properties on these two strains.
Indolizine carboxylic acids synthesized using TPCD show promising antibacterial properties against escherichia coli and staphylococcus aureus, with compound 3c showing the best antimicrobial properties.
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