The synthesis of a new series of 1 -methylcarbapenems having 5-(1,2-disubstituted ethyl)pyrrolidine moiety are described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. Among them, compound (IIIc) having 1-methoxyimino-2-hydroxyethyl moiety showed the most potent antibacterial activity.

The new series of 1-methylcarbapenems with 5-(1,2-disubstituted ethyl)pyrrolidine moiety show potent antibacterial activity against both Gram-positive and Gram-negative bacteria.

Paper

Synthesis and Antibacterial Activity of 1β-Methyl-2-[5-(1,2-disubstituted ethyl)-pyrrolidin-3-ylthio]carbapenem derivatives. Part III

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