Paper

Synthesis and anticancer activities of some novel 2-(benzo[d]thiazol-2-yl)-8-substituted-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones.

Published Apr 1, 2011 · R. Reis, E. C. Azevedo, M. de Souza

European journal of medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

Novel compounds 3b and 3c show good anticancer activity against MDA-MB-435, HL-60, HCT-8, and SF-295 human cancer cell lines, with medium tumorigenic and irritant risks compared to doxorubicin.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and anticancer activities of some novel 2-(benzo[d]thiazol-2-yl)-8-substituted-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones.

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