Synthesis and in vitro anticancer activity of 6,7-methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-one analogs.

doi:10.1016/j.ejmech.2011.10.017

Paper

Synthesis and in vitro anticancer activity of 6,7-methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-one analogs.

Published Dec 1, 2011 · Chien‐Ting Chen, Mei‐Hua Hsu, Yung-Yi Cheng

European journal of medicinal chemistry

Q2 SJR score

30

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Abstract

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In Vitro Study

Study Snapshot

6,7-methylenedioxy-2-(5-methylselenophen-2-yl)quinolin-4-one (4d) shows promising anticancer activity against MDA-MB-435 melanoma, warranting further optimization.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and in vitro anticancer activity of 6,7-methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-one analogs.

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