Paper
Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
Published Sep 1, 2009 · S. Karakuş, Ş. Güniz Küçükgüzel, I. Küçükgüzel
European journal of medicinal chemistry
Q2 SJR score
54
Citations
1
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide show promising antiviral activity against HIV-1 and HIV-2, but not significant anticancer properties.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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The structural requirements for designing more potent thiourea analogues against influenza virus neuraminidase include atom type, log P, and shadow indices, which significantly contribute to inhibitory activity.
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Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
Novel thiourea derivatives show moderate protection against Coxsackie virus B4, 79% inhibition against Mycobacterium tuberculosis H37Rv, and potential antiviral activity against HIV and other viruses.
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CNDCT is a new thiourea derivative with inhibitory activity against Farnesoid X receptor, showing good non-ionizing potential compared to urea.
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