Synthesis, in vitro anticancer activity and SAR studies of arylated imidazo[1,2-a]pyrazine–coumarin hybrids

doi:10.1039/C5RA00584A

Paper

Synthesis, in vitro anticancer activity and SAR studies of arylated imidazo[1,2-a]pyrazine–coumarin hybrids

Published Apr 23, 2015 · Richa Goel, Vijay Luxami, Kamaldeep Paul

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32

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Abstract

A new series of imidazo[1,2-a]pyrazine–coumarin hybrids have been synthesized by the combination of two biologically active moieties, imidazo[1,2-a]pyrazine and coumarin, followed by the Suzuki–Miyaura cross coupling reaction for monoarylation at the C6 position and symmetrical/unsymmetrical diarylation at the C3 and C6 positions. These compounds were further screened for their in vitro antitumor activities.

Study Snapshot

The synthesized imidazo[1,2-a]pyrazine-coumarin hybrids show promising in vitro antitumor activity and show potential for further development as potential cancer treatments.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis, in vitro anticancer activity and SAR studies of arylated imidazo[1,2-a]pyrazine–coumarin hybrids

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References

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Citations

A Review on Design of Coumarin Hybrids in the Treatment of Breast Cancer

Coumarin hybrids show potential as potent antidotes for breast cancer due to their minimal toxicity in multiple organ systems.

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