Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells.

doi:10.1016/j.bmcl.2014.11.083

Paper

Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells.

Published Feb 1, 2015 · R. Kumbhare, T. Dadmal, M. J. Ramaiah

Bioorganic & medicinal chemistry letters

Q2 SJR score

42

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Abstract

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In Vitro Study

Study Snapshot

Novel triazole-linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives show potential in controlling cell proliferation and invasion in highly malignant breast cancers by inhibiting key proteins.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells.

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