Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines

doi:10.3797/SCIPHARM.2006.74.1

Paper

Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines

Published Mar 1, 2006 · M. Aboul-Enein, A. El-Azzouny, F. Ragab

Scientia Pharmaceutica

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Abstract

The synthesis of certain N-aralkyl(1-aminomethylcyclohexyl) benzenamines 6a-i, N-(alkyloxymethyl or aralkyloxymethylcyclohexyl)-N-arylbenzenamines 9a-l and 1-(1-(aralkylphenylamino)cyclohexyl methoxy)-3-isopropylaminopropan-2-ols 11a-c has been accomplished. These compounds exhibited anticonvulsant activity. Compounds 9h, 9b and 11a at doses 0.06, 0.075 and 0.08 mmol/kg, respectively provoked maximal anticonvulsant potential against pentylenetetrazol (PTZ) induced seizures test compared with diphenylhydantoin (0.2 mmol/kg) and valproic acid (0.24mmol/kg).

Non-RCT

Study Snapshot

N-aralkyl-N-(1-substituted Cyclohexyl) benzenamines show anticonvulsant activity, with compounds 9h, 9b, and 11a showing the highest potential against pentylenetetrazol-induced seizures compared to dipheny

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines

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References

Citations

Exploring new cyclohexane carboxamides based GABA agonist: Design, synthesis, biological evaluation, in silico ADME and docking studies.

New cyclohexane carboxamides-based GABA agonists show promising anticonvulsant potential, with compounds 6d and 6e showing the most potent activity in chemically induced seizures.

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The microwave-assisted tungstophosphoric acid (H3PW12O40) catalyzed method effectively synthesizes versatile enaminoketones with reasonable anti-inflammatory and anti-oxidant activities.

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Design and synthesis of certain substituted cycloalkanecarboxamides structurally related to safinamide with anticonvulsant potential Mohamed N. Aboul-EneinAida A. El-Azzouny • Yousreya A. MakladMohamed A. Ismail • Nasser S. M. IsmailRasha M. Hassan

Novel safinamide derivatives show anticonvulsant potential, with compound 13b showing the most activity in the subcutaneous pentylenetetrazole screening test.

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N-aralkyl-N-(1-((cyclohexylamino)methyl)cyclohexyl)benzenamines and benzamides show promising anticonvulsant and analgesic properties, with the most active compounds showing 100% protection in mice compared to diphen