Short Synthesis of the Antidiabetic Octaketide Ethyl 2-(2,3,4-Trimethoxy-6-octanoylphenyl)acetate

doi:10.1055/s-0036-1592062

Paper

Short Synthesis of the Antidiabetic Octaketide Ethyl 2-(2,3,4-Trimethoxy-6-octanoylphenyl)acetate

Published Nov 28, 2017 · Wei Sun, Yue Yuan, Bit Lee

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Abstract

Abstract A facile and practical approach for the synthesis of ethyl 2-(2,3,4-trimethoxy-6-octanoylphenyl)acetate, an antidiabetic octaketide analogue of cytosporone B, is described. Unlike known approaches for the synthesis of cytosporones and their analogues, the key step of the developed route is a Friedel–Crafts alkylation of 1-(3,4,5-trimethoxyphenyl)octan-1-one with ethyl chloro(methylthio)acetate, followed by desulfurization.

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This study presents a facile and practical approach for the synthesis of ethyl 2-(2,3,4-trimethoxy-6-octanoylphenyl)acetate, an antidiabetic octaketide analogue of cytosporone B, using Friede

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Short Synthesis of the Antidiabetic Octaketide Ethyl 2-(2,3,4-Trimethoxy-6-octanoylphenyl)acetate

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References

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This study presents a method for synthesis of biologically active octaketide natural products, including cytosporone B, with high reactivity and regioselectivity at low catalyst loadings.

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Spike-timing dependent plasticity and periodic modulation of presynaptic firing rates in feed-forward networks can produce precise and invariant spike phase-locking in neurons, with implications for stable learning of spike-timing in the hippocampus.

A unique pharmacophore for activation of the nuclear orphan receptor Nur77 in vivo and in vitro.

Csn-B-derived Nur77 agonists show potential as a new class of potent and effective antitumor agents by stimulating proliferation, differentiation, and apoptosis.

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