Paper
Synthesis, antimicrobial and antifungal activities of novel 1H-1,4-diazepines containing pyrazolopyrimidinone moiety
Published Aug 27, 2009 · R. Kumar, Y. Joshi
Journal of Chemical Sciences
Q3 SJR score
25
Citations
0
Influential Citations
Abstract
Acylation of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo [4,3-d) pyrimidin-7-one 1 with chloroacetylchloride in the presence of anyhydrous aluminium chloride affords 5-[(5-chloroacetyl-2-ethoxy)phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo [4,3-d] pyrimidin-7-one 2. The compound 2 condensed with various β-diketones/β-ketoesters compound, to obtain new β-diketones/β-ketoesters 4a-i treated with ethylenediamine (EDA) gives 1H-1,4-diazepines. The compounds 5a-i has been screened for antimicrobial, antifungal and anthelmintic activities.
Study Snapshot
Novel 1H-1,4-diazepines with pyrazolopyrimidinone moiety show promising antimicrobial, antifungal, and anthelmintic activities.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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