Synthesis and Antifungal Potential of 3-{4′-(Chlorobenzyloxy)-phenyl}-4-amino-5-mercapto-1,2,4-triazoles and Their Derivatives.

doi:10.1002/CHIN.201332149

Paper

Synthesis and Antifungal Potential of 3-{4′-(Chlorobenzyloxy)-phenyl}-4-amino-5-mercapto-1,2,4-triazoles and Their Derivatives.

Published Aug 6, 2013 · Nisheeth Rastogi, P. Kant, R. Sethi

ChemInform

0

Citations

0

Influential Citations

Full text

Abstract

: 3-{4'-(Chlorobenzyloxy)-phenyl}-4-amino-5-mercapto-1,2,4-triazoles (la-d) were prepared by treating 4-(chlorobenzyloxy)-benzoylhydrazines successively with alcoholic potassium hydroxide-carbon disulphide and hydrazine hydrate, which on reaction with hydrazine hydrate, carbon disulphide, benzoic acid, benzoin, phenacyl bromide, phenyl isothiocyanate, formic acid, chloroacetyl chloride, benzaldehyde and isatin gave condensed bridgehead heterocycles (triazolo-thiadiazoles and triazolo-thiadiazines). The structures of the compounds were established with the help of elemental analysis and spectral data (IR, PMR and Mass). Compounds were screened for their antimycotic potential against human pathogenic fungi.

Study Snapshot

3-4′-(chlorobenzyloxy)-phenyl-4-amino-5-mercapto-1,2,4-triazoles (la-d) show promising antifungal potential against human pathogenic fungi.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and Antifungal Potential of 3-{4′-(Chlorobenzyloxy)-phenyl}-4-amino-5-mercapto-1,2,4-triazoles and Their Derivatives.

References

Citations