Synthesis and Antifungal Properties of N-[(1,1′-Biphenyl)-4-ylmethyl]-1H-imidazol-1-amine Derivatives.

doi:10.1002/CHIN.200314122

Paper

Synthesis and Antifungal Properties of N-[(1,1′-Biphenyl)-4-ylmethyl]-1H-imidazol-1-amine Derivatives.

Published Apr 8, 2003 · Maria Giovanna Setzu, G. Stefancich, P. Colla

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Abstract

Abstract In the course of a study on 1H-imidazol-1-amine derivatives as antifungal agents, we found that N-[(1,1′-biphenyl)-4-ylmethyl]-N-[(2,4-dichlorophenyl)methyl]-1H-imidazol-1-amine (1a) exhibited promising activities. In order to explore more in detail the structure–activity relationship of this new class of antifungal agents, we report now the synthesis and the biological activity of new analogues (1b–k) of compound 1a. The synthesis was performed using N-[(1,1′-biphenyl)-4-ylmethyl]-1H-imidazol-1-amine as starting material which was reacted with the proper arylmethyl halide. Most of the newly synthesized imidazolamines exhibited both fungal growth inhibition activity and cellular selectivity.

In Vitro Study

Study Snapshot

N-[(1,1′-biphenyl)-4-ylmethyl]-1H-imidazol-1-amine derivatives show promising antifungal properties and cellular selectivity, offering a new class of antifungal agents for further exploration.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and Antifungal Properties of N-[(1,1′-Biphenyl)-4-ylmethyl]-1H-imidazol-1-amine Derivatives.

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