Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds.

doi:10.1021/JM00368A019

Paper

Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds.

Published Feb 1, 1984 · A. Terada, S. Naruto, K. Wachi

Journal of medicinal chemistry

Q1 SJR score

43

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0

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Abstract

[(Cycloalkylmethyl)phenyl]acetic acid derivatives and related compounds were synthesized to test their antiinflammatory and analgesic activities. Some of the compounds in this series were found to have good activity in the carrageenan edema test. Among them, sodium 2-[4-[(2-oxocyclopentyl)methyl] phenyl]propionate dihydrate (15) and 2-[4-[(2-oxocyclohexylidene)methyl]phenyl]propionic acid (13b) showed potent analgesic and antiadjuvant arthritis activities with excellent antipyretic properties.

In Vitro Study

Study Snapshot

[(Cycloalkylmethyl)phenyl]acetic acid derivatives show potent analgesic and antiinflammatory properties, with sodium 2-[4-[(2-oxocyclopentyl)methyl] phenyl]propionate dihydrate showing potent analgesic and anti

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds.

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