4-(3-Dimethylaminopropionyl)-l,2-dimethoxybenzene displays anti-inflammatory activity and has low toxicity [1]. In order to study the relationship between chemical structure and pharmacological properties and to search for new pharmaceutical preparations, we have synthesized and investigated new derivatives of the above aminoketone (Ha-c) that conta:,a alkyl substituents in the aromatic ring. Aminoketone hydrochlorides l/a-c were obtained by means of the Mannich reaction from the interaction between the appropriate ketones (la-c), dimethylamine hydrochloride, and formaldehyde.

1-alkyl-2-[3-dimethylaminopropionyl]-4,5-dimethoxybenzenes show anti-inflammatory activity and low toxicity, suggesting potential as new pharmaceutical preparations.

Paper

Synthesis and anti-inflammatory activity of 1-alkyl-2-[3-dimethylaminopropionyl]-4,5-dimethoxybenzenes

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