Synthesis and anti-inflammatory activity of 1-alkyl-2-[3-dimethylaminopropionyl]-4,5-dimethoxybenzenes

doi:10.1007/BF02218949

Paper

Synthesis and anti-inflammatory activity of 1-alkyl-2-[3-dimethylaminopropionyl]-4,5-dimethoxybenzenes

Published 2005 · V. K. Daukshas, P. Gaidyalis, V. A. Kuleshyus

Pharmaceutical Chemistry Journal

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Abstract

4-(3-Dimethylaminopropionyl)-l,2-dimethoxybenzene displays anti-inflammatory activity and has low toxicity [1]. In order to study the relationship between chemical structure and pharmacological properties and to search for new pharmaceutical preparations, we have synthesized and investigated new derivatives of the above aminoketone (Ha-c) that conta:,a alkyl substituents in the aromatic ring. Aminoketone hydrochlorides l/a-c were obtained by means of the Mannich reaction from the interaction between the appropriate ketones (la-c), dimethylamine hydrochloride, and formaldehyde.

Study Snapshot

1-alkyl-2-[3-dimethylaminopropionyl]-4,5-dimethoxybenzenes show anti-inflammatory activity and low toxicity, suggesting potential as new pharmaceutical preparations.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and anti-inflammatory activity of 1-alkyl-2-[3-dimethylaminopropionyl]-4,5-dimethoxybenzenes

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References

The pharmacology of benoxaprofen (2‐[4‐chlorophenyl]‐α‐methyl‐5‐benzoxazole acetic acid), LRCL 3794, a new compound with anti‐inflammatory activity apparently unrelated to inhibition of prostaglandin synthesis

Benoxaprofen is a potent and long-acting anti-inflammatory and antipyretic compound with low ulcerogenic potential, potentially due to its inability to inhibit prostaglandin synthesis.

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

Carrageenin-induced edema in rats can be used as an assay for antiinflammatory drugs, with potency ratios similar to those in rheumatoid arthritis treatment.

SOME DERIVATIVES OF DIALKOXY-PHTHALIDES

Dialkoxy-phthalides with chloromethyl groups can be synthesized, yielding various intermediate aldehydes and compounds derived from them.

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