Synthesis and antiinflammatory activity of 3-substituted-4-amino-5-mercapto-4(h)-1,2,4-triazole.

Paper

Synthesis and antiinflammatory activity of 3-substituted-4-amino-5-mercapto-4(h)-1,2,4-triazole.

Published May 1, 1993 · M. Hosur, M. Talwar, R. Bennur

Indian Journal of Pharmaceutical Sciences

Q3 SJR score

10

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0

Influential Citations

Semantic Scholar

Abstract

"Various 3-substituted-4-amino-5-mercapto-4(H)- 1,2,4-triazoles were synthesised by treating morpholine/piperidine acetic/propionic/(alpha-methyl) propionic acid hydrazides successively with alcoholic potassium hydroxide-carbondisulfide and hydrazine hydrate.All the compounds were screened for their antiinflammatory activity against carrageenan induced rat paw edema and cotton pellet granuloma pouch at mg/100 grams B.W. Three compounds [B,C,D] were found to have significant activity. The detailed antiinflammatory activity and acute toxicity were studied, the former in comparison with phenyl butazone."

In Vitro Study

Study Snapshot

Three 3-substituted-4-amino-5-mercapto-4(H)-1,2,4-triazoles show significant antiinflammatory activity and low acute toxicity compared to phenyl butazone.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and antiinflammatory activity of 3-substituted-4-amino-5-mercapto-4(h)-1,2,4-triazole.

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References

Citations

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