The compound 4-(3-dimethylaminopropionyl)-l,2-dimethoxybenzene (I) shows high antiinfiammatory activity (AIA) and has low toxicity [1]. With the object of studying the dependence between the chemical structure and the AIA, as well as seeking new medicinal agents, we investigated the biotransformation of the aminoketone (I) in the rabbk organism and the AIA of its metabolites (II)-(IV), (VIII), and (IX).

The metabolites of 4-(3-dimethylaminopropionyl)-1,2-dimethoxybenzene show high antiinflammatory activity and low toxicity, offering potential as new medicinal agents.

Paper

Synthesis and antiinflammatory activity of metabolites of 4-(3-dimethylaminopropionyl)-1,2-dimethoxybenzene

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