A series of ethyl 4-(2-aryloxyhexyloxy)benzoates was prepared and tested for their activity to induce precocious metamorphosis in larvae of the silkworm. Phenyl analog 5 showed activity comparable to that of the 6-methyl-3-pyridyl analog reported as a novel anti-JH agent. The activity of 5 could be fully counteracted by methoprene, a JH agonist. The ethoxycarbonyl group of 5 was essential for its activity.

Ethyl 4-(2-aryloxyhexyloxy)benzoates show potential as anti-juvenile hormone agents, with phenyl analog 5 showing comparable activity to 6-methyl-3-pyridyl, but their activity can be counteracted by methoprene.

Paper

Synthesis and Anti-Juvenile Hormone Activity of Ethyl 4-(2-Aryloxyhexyloxy)benzoates

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