Synthesis and in vitro Antimicrobial Activity of New Ethyl 2‐(Ethoxyphosphono)‐1‐cyano‐2‐(substituted tetrazolo[1,5‐a]quinolin‐4‐yl)ethanoate Derivatives

doi:10.1002/CJOC.201090060

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Synthesis and in vitro Antimicrobial Activity of New Ethyl 2‐(Ethoxyphosphono)‐1‐cyano‐2‐(substituted tetrazolo[1,5‐a]quinolin‐4‐yl)ethanoate Derivatives

Published Feb 1, 2010 · Amol H. Kategaonkar, Sandip A. Sadaphal, K. Shelke

Chinese Journal of Chemistry

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Abstract

A series of new ethyl 2-(ethoxyphosphono)-1-cyano-2-(substituted tetrazolo[1,5-a]quinolin-4-yl)ethanoate derivatives have been synthesized for the first time of tetrazolo[1,5-a]quinoline derivatives. Elemental analysis, IR, 1H NMR, 13C NMR, 31P NMR and mass spectral data elucidated the structures of the all newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. Significantly microbiological behavior of these newly synthesized derivatives possesses significant antibacterial and antifungal activity.

Study Snapshot

New ethyl 2-(ethoxyphosphono)-1-cyano-2-(substituted tetrazolo[1,5-a]quinolin-4-yl)ethanoate derivatives show significant antibacterial and antifungal activity against Gram-positive Bacillus subtil

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and in vitro Antimicrobial Activity of New Ethyl 2‐(Ethoxyphosphono)‐1‐cyano‐2‐(substituted tetrazolo[1,5‐a]quinolin‐4‐yl)ethanoate Derivatives

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