Synthesis and Antimicrobial Activity of New Quaternary Ammonium Chlorides

doi:10.1002/CHIN.199643050

Paper

Synthesis and Antimicrobial Activity of New Quaternary Ammonium Chlorides

Published Oct 22, 1996 · B. Brycki, A. Skrzypczak, I. Mirska

Archiv der Pharmazie

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3

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0

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Abstract

Decyldimethylamine reacts readily with chloromethylalkyl ethers or sulfides, chloromethylbezyl ethers or sulfides and chloromethylcycloalkyl ethers to give quaternary ammonium chlorides in very good yields. All the chlorides studied showed antimicrobial activity. The relationship between the chemical structure and antimicrobial activity was analyzed by rough sets.

Study Snapshot

New quaternary ammonium chlorides synthesized from decyldimethylamine show promising antimicrobial activity, with their chemical structure playing a key role in their effectiveness.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and Antimicrobial Activity of New Quaternary Ammonium Chlorides

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References

Rough sets in the analysis of the structure-activity relationships of antifungal imidazolium compounds.

The rough sets approach effectively analyzes the structure-activity relationships of antifungal imidazolium compounds, aiding in synthesis decisions.

Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.

Select imidazolium compounds, when combined with atropine sulfate, provide lifesaving protection against organophosphorus-inhibited acetylcholinesterases, offering a potential alternative antidotal mechanism.

Effect of alkyl chain length of benzalkonium chloride on the bactericidal activity and binding to organic materials.

C12-benzalkonium chloride is the most effective component of benzalkonium chloride homologues for bactericidal activity and binding to organic materials.

Citations

Ammonium Gemini Surfactants Form Complexes with Model Oligomers of siRNA and dsDNA

Ammonium gemini surfactants form stable lipoplexes with siRNA and dsDNA oligomers, potentially serving as effective carriers for therapeutic nucleic acid transfection in gene therapy.

Analysis of Relationships Between Structure, Surface Properties, and Antimicrobial Activity of Quaternary Ammonium Chlorides

Structure and surface-active properties of quaternary ammonium chlorides significantly influence their antimicrobial activity, providing guidelines for synthesis of new compounds with preferable antimicrobial properties.

Synthesis and antimicrobial activities of new pyridinium and benzimidazolium chlorides.

New pyridinium and benzimidazolium chlorides show strong antimicrobial activities against various bacteria, showing wide antibacterial spectrum similar to benzalkonium chloride.