Synthesis and Antimicrobial activity of Some 1, 3, 4- Oxadiazoles-2-thione and 1, 2, 4-Triazoles Derivatives from Tert-Butyl Carbazate

doi:10.13005/OJC/290219

Paper

Synthesis and Antimicrobial activity of Some 1, 3, 4- Oxadiazoles-2-thione and 1, 2, 4-Triazoles Derivatives from Tert-Butyl Carbazate

Published Jun 22, 2013 · A. Ghoneim, S. Mohamed

Oriental journal of chemistry

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Abstract

Tert-butyl carbazate (1) reacted with ammonium thiocyanate and phenyl isothiocyanate to afford the corresponding 5-tert-butoxy-4H-1, 2, 4-triazole-3-thiol (3) 5-tert-butoxy-4-phenyl-2H1, 2, 4-triazole-3(4H)-thione 5 respectively. Compound (1) also reacted with carbon disulfide and potassium hydroxide to afford 5-tert-butoxy-1, 3, 4-oxadiazole-2(3H)-thione 6. Treatment of 6 with methyl iodide, 2, 3, 4, 6-tetra-O-acetyl-â-D-glucopyranosyl bromide and hydrazine hydrate to give the corresponding compounds (7, 8, 10) respectively. Reaction of 8 with ammonia gave the corresponding 9. Treatment compound 10 with 2-bromo-1-phenylethanone to give the corresponding 11. All new compounds were characterized by 1HNMR, IR Spectroscopy and elemental analysis. The biological activity of the prepared compounds was also described.

Study Snapshot

Tert-butyl carbazate-derived compounds show promising antimicrobial activity against various bacteria and fungi.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and Antimicrobial activity of Some 1, 3, 4- Oxadiazoles-2-thione and 1, 2, 4-Triazoles Derivatives from Tert-Butyl Carbazate

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References

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Citations

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