Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of substituted 3-chloro-5,8-dimethoxy-1,4-naphthoquinone and related compounds.

doi:10.1016/S0968-0896(98)80006-0

Paper

DOI: 10.1016/S0968-0896(98)80006-0

Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of substituted 3-chloro-5,8-dimethoxy-1,4-naphthoquinone and related compounds.

Published Dec 1, 1998 · L. J. Huang, Fu Chaio Chang, K. Lee

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

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Substituted 3-chloro-5,8-dimethoxy-1,4-naphthoquinone and related compounds show potent antiplatelet, antiinflammatory, and antiallergic activities, with compounds 5 and 9-11 showing particularly active effects.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1016/S0968-0896(97)00133-8

Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of 2-substituted 3-chloro-1,4-naphthoquinone derivatives.

2-substituted 3-chloro-1,4-naphthoquinone derivatives show potent antiplatelet, antiinflammatory, and antiallergic activities, with similar trends in each evaluated activity.

1997·49citations·J. Lien et al.·Bioorganic & medicinal chemistry

Bioorganic & medicinal chemistry

DOI: 10.1248/CPB.44.1181

Synthesis and antiplatelet, antiinflammatory and antiallergic activities of 2,3-disubstituted 1,4-naphthoquinones.

2,3-disubstituted 1,4-naphthoquinones show significant antiplatelet, antiallergic, and antiinflammatory activities, with 2-methoxy-3-chloro-1,4-naphthoquinone (15) and 2-ethoxy-3-chlor

1996·43citations·J. Lien et al.·Chemical & pharmaceutical bulletin

Chemical & pharmaceutical bulletin

DOI: 10.1016/0014-2999(89)90836-4

Edematous response caused by [Thi5,8,D-Phe7]bradykinin, a B2 receptor antagonist, is due to mast cell degranulation.

The edematous response caused by [Thi 5,8,D-Phe 7]bradykinin is mainly due to mediators released by mast cell degranulation, making it a useful tool for evaluating kinin's role in inflammation.

1989·21citations·J. P. Wang et al.·European journal of pharmacology

European journal of pharmacology

DOI: 10.1172/JCI109008

Superoxide production by digitonin-stimulated guinea pig granulocytes. The effects of N-ethyl maleimide, divalent cations; and glycolytic and mitochondrial inhibitors on the activation of the superoxide generating system.

The activation of the superoxide generating system in guinea pig granulocytes is N-ethylmaleimide sensitive, calcium dependent, and energy requiring, but not enzyme-dependent.

1978·164citations·H. Cohen et al.·The Journal of clinical investigation

The Journal of clinical investigation

DOI: 10.1016/0003-2697(74)90267-X

Improved fluorometric assay of histamine: Condensation with O-phthalaldehyde at −20°C

The improved fluorometric assay for histamine is more specific and efficient, allowing for measurements as low as 1 ng/ml and saving time and labor.

1974·83citations·R. Håkanson et al.·Analytical Biochemistry

Analytical Biochemistry

Citations

DOI: 10.1016/j.thromres.2023.08.013

Regulation of mitochondrial function by hydroquinone derivatives as prevention of platelet activation.

Hydroquinone derivatives effectively prevent platelet activation by regulating mitochondrial function, offering potential as a new antiplatelet drug target.

2023·6citations·E. Fuentes et al.·Thrombosis research

Thrombosis research

DOI: 10.1016/j.biopha.2023.114690

An overview on the antibacterial properties of juglone, naphthazarin, plumbagin and lawsone derivatives and their metal complexes.

New 1,4-naphthoquinones hydroxyderivatives and their metal complexes show promising antibacterial activity against various bacterial strains, including resistant ones, offering potential as new antibiotic alternatives.

2023·14citations·Chaimae Majdi et al.·Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI: 10.3390/molecules27175645

Synthesis of thia-Michael-Type Adducts between Naphthoquinones and N-Acetyl-L-Cysteine and Their Biological Activity

Novel 1,4-naphthoquinone derivatives show potential as antitumoral agents by inducing ROS generation and cytotoxicity in various cancer cell lines.

2022·3citations·G. Micheletti et al.·Molecules

Molecules

DOI: 10.3390/molecules26195878

Computational Screening of Natural Compounds for Identification of Potential Anti-Cancer Agents Targeting MCM7 Protein

UEFS99, UEFS137, and UEFS428 show potential as non-toxic, drug-like inhibitors against MCM7 protein, which may help fight cancers.

2021·14citations·Mohammad Y. Alshahrani et al.·Molecules

Molecules

DOI: 10.1007/s11164-020-04375-6

Highly efficacious preparation of 3,3′-(arylmethylene)-bis(2-hydroxynaphthoquinone) derivatives catalyzed by a nanorod-structured organic–inorganic hybrid material

Nanorod-structured organic-inorganic hybrid material effectively catalyzes solvent-free preparation of 3,3′-(arylmethylene)-bis(2-hydroxynaphthoquinone) derivatives in high yields and short time, offering a promising approach for industrial applications.

2021·1citation·A. Zare et al.·Research on Chemical Intermediates

Research on Chemical Intermediates

DOI: 10.1016/j.bcp.2020.114341

Synthesis And Pharmacological Evaluation Of Acylhydroquinone Derivatives As Potent Antiplatelet Agents.

Acylhydroquinone derivatives show promising antiplatelet activity, with compound 38 showing the highest activity against platelet aggregation and inhibiting P-selectin and granulophysin expression.

2020·11citations·Diego Méndez et al.·Biochemical pharmacology

Biochemical pharmacology

DOI: 10.1016/j.jinorgbio.2020.111289

Lapachol in the Design of a New Ruthenium(II)-Diphosphine Complex as a Promising Anticancer Metallodrug.

Lapachol and Lawsone can form new ruthenium compounds with promising anticancer properties, particularly against triple-negative breast cancer cells.

2020·25citations·Katia M. Oliveira et al.·Journal of inorganic biochemistry

Journal of inorganic biochemistry

DOI: 10.1007/s12039-020-01835-9

New vitamin K3 (menadione) analogues: synthesis, characterization, antioxidant and catalase inhibition activities

New vitamin K3 analogues show catalase inhibition activity and antioxidant capacity, with compound 13 showing remarkable potency against catalase enzyme.

2020·3citations·N. Deniz et al.·Journal of Chemical Sciences

Journal of Chemical Sciences

DOI: 10.29121/granthaalayah.v7.i10.2019.399

SYNTHETIC AND BIOLOGICAL UTILITY OF 2,3-DICHLORO-1,4-NAPHTHOQUINONE: A REVIEW

2,3-dichloro-1,4-naphthoquinones have shown potential in synthesizing biologically active compounds with potential antifungal, antibacterial, anticancer, and anti-inflammatory properties.

2020·3citations·Hardesh K. Maurya·International Journal of Research

International Journal of Research