Paper

Synthesis, antiprotozoal activity, and chemoinformatic analysis of 2-(methylthio)-1H-benzimidazole-5-carboxamide derivatives: Identification of new selective giardicidal and trichomonicidal compounds.

Published Sep 8, 2017 · Paulina Flores-Carrillo, J. Velázquez-López, R. Aguayo‐Ortiz

European journal of medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

New 2-(methylthio)-1H-benzimidazole-5-carboxamide derivatives show promising antiparasitic activity against Giardia intestinalis, Trichomonas vaginalis, and Entamoeba histolytica, with compounds 1 and 3 showing notable selective effects.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis, antiprotozoal activity, and chemoinformatic analysis of 2-(methylthio)-1H-benzimidazole-5-carboxamide derivatives: Identification of new selective giardicidal and trichomonicidal compounds.

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