Paper
Synthesis, antituberculosis activity, and DNA binding affinity of a highly diverse library of 1,4-diarylpiperazines
Published 2003 · J. V. Eynde, A. Mayence, Louis F. LeCour
Medicinal Chemistry Research
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Abstract
A library of eighteen 1,4-diarylpiperazines has been synthesized and evaluated for antituberculosis activity and DNA binding affinity. Among them, 4,4'-(1,4-piperazinediyl)bis(N-alkylbenzenecarboximidamides) emerged as attractive leads for further drug development.
Study Snapshot
A diverse library of 1,4-diarylpiperazines shows promising antituberculosis activity and DNA binding affinity, with 4,4'-(1,4-piperazinediyl)bis(N-alkylbenzenecarboximidamides) emerging as attractive leads for further drug
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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