Synthesis and antituberculosis activity of novel mefloquine-isoxazole carboxylic esters as prodrugs.

doi:10.1016/j.bmcl.2009.11.105

Paper

Synthesis and antituberculosis activity of novel mefloquine-isoxazole carboxylic esters as prodrugs.

Published Feb 1, 2010 · J. Mao, Hai Yuan, Yuehong Wang

Bioorganic & medicinal chemistry letters

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66

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Abstract

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In Vitro Study

Study Snapshot

Novel mefloquine-isoxazole carboxylic esters show excellent antituberculosis activity, with potential as prodrugs for improving anti-TB potency.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and antituberculosis activity of novel mefloquine-isoxazole carboxylic esters as prodrugs.

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