Synthesis and Antitumor Activities of N-(2′-arylaminepyrimidin4′-yl)-N,2,3-trimethyl-2H-indazol-6-amine Derivatives

Paper

Synthesis and Antitumor Activities of N-(2′-arylaminepyrimidin4′-yl)-N,2,3-trimethyl-2H-indazol-6-amine Derivatives

Published 2011 · Chu De-qing

Chinese Journal of Synthetic Chemistry

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Abstract

A key medicine intermedia,N-(2′-chloropyrimidin-4′-yl)-N,2,3-trimethyl-2H-indazol-6-amine(5),was obtained by N-methylation,catalytic reduction,nucleophilic substitution and alkylated reaction from 3-methyl-6-nitro-1H-indazole.Eleven novel N-(2′-arylaminepyrimidin-4′-yl)-N,2,3-trimethyl-2H-indazol-6-amine derivatives were synthesized by nucleophilic substitution of 5 with arylamine.The structures were characterized by 1H NMR and EI-MS.The preliminary bioassay test indicates that some of them exhibited obvious antitumor activities.

Study Snapshot

N-(2′-arylaminepyrimidin-4′-yl)-N,2,3-trimethyl-2H-indazol-6-amine derivatives show promising antitumor activities in preliminary bioassay tests.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and Antitumor Activities of N-(2′-arylaminepyrimidin4′-yl)-N,2,3-trimethyl-2H-indazol-6-amine Derivatives

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