Synthesis and antitumor activities research of 5-(4-chlorophenyl)-N,N-dimethyl-7-(trifluoromethyl) pyrazolo pyrimidine-3-carboxamide

Paper

Synthesis and antitumor activities research of 5-(4-chlorophenyl)-N,N-dimethyl-7-(trifluoromethyl) pyrazolo pyrimidine-3-carboxamide

Published 2012 · Z. Xin

Journal of Harbin Medical University

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Abstract

Objective To synthesize 5-(4-chlorophenyl)-N,N-dimethyl-7-(trifluoromethyl) pyrazolo pyrimidine-3-carboxamide,and to assay its antitumor activities.Methods Based on the general structure of pyrazolo pyrimidine processing antitumor activity,5-(4-chlorophenyl)-N,N-dimethyl-7-(trifluoromethyl) pyrazolo pyrimidine-3-carboxamide was designed,and the target compound was synthesized via a 4-step procedure starting from Ethyl(ethoxymethylene) cyanoacetate and 4-Chloroacetophenone.With CTX as a positive control,the target compound for anti-tumor activity was measured in vivo.Results Three novel compounds were synthesized,and their structures were confirmed by IR and 1 H-NMR.Conclusion Compound 7 displays good antitumor activities.

In Vitro Study

Study Snapshot

Compound 7 shows good antitumor activities, making it a promising candidate for future antitumor treatments.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and antitumor activities research of 5-(4-chlorophenyl)-N,N-dimethyl-7-(trifluoromethyl) pyrazolo pyrimidine-3-carboxamide

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