Synthesis and in-vitro antitumor activity of 1-[3-(indol-1-yl)prop-1-yn-1-yl]phthalazines and related compounds.
Published Aug 17, 2007 · N. Haider, Tamara Kabicher, J. Kaeferboeck
Molecules
Q1 SJR score
26
Citations
0
Influential Citations
Abstract
A series of novel 3-(indol-1-yl)prop-1-yn-1-yl-substituted phthalazines and related azines was prepared via a concise pathway by palladium-catalyzed cross-coupling of appropriate halo-azines and N-propargylindoles. Some of the compounds exhibited significant antitumor activity in an in-vitro assay.
Study Snapshot
Key takeawayNovel 3-(indol-1-yl)prop-1-yn-1-yl-substituted phthalazines show potential antitumor activity in vitro.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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