Synthesis and antitumor evaluation of novel derivatives of 6-amino-2-phenylbenzothiazoles.

doi:10.3390/11050325

Paper

Synthesis and antitumor evaluation of novel derivatives of 6-amino-2-phenylbenzothiazoles.

Published May 9, 2006 · L. Racané, R. Stojković, V. Tralić-Kulenović

Molecules

Q1 SJR score

33

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0

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Abstract

Novel derivatives of 6-amino-2-phenylbenzothiazole bearing different substituents (amino, dimethylamino or fluoro) on the phenyl ring were prepared as the corresponding hydrochloride salts. 6-Nitro-2-(substituted-phenyl)benzothiazoles (1-6) were synthesized by condensation reactions of substituted benzaldehydes with 2-amino-5-nitrothiophenol. Nitro derivatives were reduced to the amino derivatives with SnCl(2)/HCl. Water soluble hydrochloride salts of 6-amino-2-(substituted-phenyl)benzothiazole (13-19)were prepared using concentrated or gaseous HCl. Compounds 13-19 were found to exert cytostatic activities against malignant human cell lines: cervical (HeLa), breast (MCF-7),colon (CaCo-2), laryngeal carcinoma (Hep-2), and normal human fibroblast cell lines (WI-38).

In Vitro Study

Study Snapshot

Novel 6-amino-2-phenylbenzothiazole derivatives show cytostatic activity against various malignant human cell lines, offering potential as a new antitumor agent.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and antitumor evaluation of novel derivatives of 6-amino-2-phenylbenzothiazoles.

References

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