Synthesis, antitumor and DNA photocleaving activities of novel naphthalene carboxamides: effects of different thio-heterocyclic rings and aminoalkyl side chains

doi:10.1016/J.TET.2005.06.097

Paper

DOI: 10.1016/J.TET.2005.06.097

Synthesis, antitumor and DNA photocleaving activities of novel naphthalene carboxamides: effects of different thio-heterocyclic rings and aminoalkyl side chains

Published Sep 1, 2005 · Zhigang Li, Qing Yang, X. Qian

Tetrahedron

Q3 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Novel naphthalene carboxamides show strong antitumor and DNA photocleaving activities, with compound 3a being the most cytotoxic against A549 and compound 4a being the strongest inhibitor for P388 leukemia cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1016/J.BMC.2005.02.045

Novel heterocyclic family of phenyl naphthothiazole carboxamides derived from naphthalimides: synthesis, antitumor evaluation, and DNA photocleavage.

The new heterocyclic family of phenyl naphthothiazole carboxamides shows potential as antitumor agents and DNA photocleavers, with B(3) being the strongest inhibitor for P388 and B(4) being the most efficient DNA photocleaver.

2005·31citations·Zhigang Li et al.·Bioorganic & medicinal chemistry

Bioorganic & medicinal chemistry

DOI: 10.1016/J.BMCL.2004.12.011

Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: intercalation and photocleavage to DNA.

Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains can effectively damage DNA from form I to II and form I to III at low concentrations, depending on the photocleaving mechanism.

2005·39citations·Yufang Xu et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

DOI: 10.1021/JM049706K

Rational design, synthesis, and biological evaluation of bis(pyrimido[5,6,1-de]acridines) and bis(pyrazolo[3,4,5-kl]acridine-5-carboxamides) as new anticancer agents.

Bis(pyrimido[5,6,1-de]acridines) and bis(pyrazolo[3,4,5-kl]acridine-5-carboxamides) show potential as new anticancer agents, with six very potent compounds selected for further in vitro studies and one for in

2004·34citations·I. Antonini et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1016/J.BMCL.2004.02.059

Highly-efficient DNA photocleavers with long wavelength absorptions: thio-heterocyclic fused naphthalimides containing aminoalkyl side chains.

Thio-heterocyclic fused naphthalimides with aminoalkyl side chains are highly efficient DNA photocleavers with long wavelength absorptions, potentially acting as superoxide anion-mediated DNA damage inhibitors.

2004·43citations·X. Qian et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

DOI: 10.1021/JM0308850

New analogues of amonafide and elinafide, containing aromatic heterocycles: synthesis, antitumor activity, molecular modeling, and DNA binding properties.

New analogues of amonafide and elinafide with aromatic heterocycles show promising antitumor activity and DNA binding properties, suggesting that DNA binding does not depend on the electronic nature of the fused heterocycle.

2004·106citations·M. Braña et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1016/J.TETLET.2003.11.145

Naphthalimide-thiazoles as novel photonucleases: molecular design, synthesis, and evaluation

Naphthalimide-thiazoles are efficient DNA intercalators and can cause DNA photodamage at low concentrations, with different activities depending on the substituents at the 2-phenyl ring.

2004·61citations·Yonggang Li et al.·Tetrahedron Letters

Tetrahedron Letters

DOI: 10.1016/S0960-894X(03)00737-6

Thiadiazole: a new family of intercalative photonuclease with electron transfer and radical mechanisms.

Thiadiazole-naphthalimide photonucleases efficiently intercalate into DNA and cause DNA damage as low as 10 M, with electron transfer and radical mechanisms involved.

2003·20citations·Yonggang Li et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

DOI: 10.1021/JM020950Q

Synthesis, antitumor activity, molecular modeling, and DNA binding properties of a new series of imidazonaphthalimides.

The new series of imidazonaphthalimides show antitumor activity in the micromolar range and DNA binding properties, with moderate activity observed for bisnaphthalimides.

2002·57citations·M. Braña et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1021/JM000473G

Kinetic studies of the binding of acridinecarboxamide topoisomerase poisons to DNA: implications for mode of binding of ligands with uncharged chromophores.

DACA, a mixed topoisomerase I/II poison, requires preferential binding to DNA to maintain its antitumor activity, with its side chains making comparable interactions with DNA base pairs.

2002·20citations·L. Wakelin et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

Citations

DOI: 10.1016/j.bcp.2022.115062

Design, synthesis and anti-tumor activity of novel benzothiophenonaphthalimide derivatives targeting mitochondrial DNA (mtDNA) G-quadruplex.

Compound 7c, a novel benzothiophenonaphthalimide derivative, shows strong anti-tumor activity in vitro and in vivo, targeting mitochondrial DNA G-quadruplex, potentially leading to liver cancer drug development.

2022·9citations·Qiong Huang et al.·Biochemical pharmacology

Biochemical pharmacology

DOI: 10.1016/J.CCLET.2018.09.020

Naphthalimides and analogues as antitumor agents: A review on molecular design, bioactivity and mechanism of action

Naphthalimide antitumor agents have shown progress in structure diversity, antitumor targets, and mechanisms of action over the past 20 years.

2018·37citations·Zhuo Chen et al.·Chinese Chemical Letters

Chinese Chemical Letters

DOI: 10.18632/oncotarget.16962

A novel triazolonaphthalimide induces apoptosis and inhibits tumor growth by targeting DNA and DNA-associated processes

LSS-11 shows potential as a novel anti-cancer agent by targeting DNA and DNA-associated processes, inducing apoptosis and inhibiting tumor growth without significant major toxicities.

2017·10citations·Liyan Ji et al.·Oncotarget

Oncotarget

DOI: 10.1016/j.jphotobiol.2017.02.009

Quinazolinone-benzimidazole conjugates: Synthesis, characterization, dihydrofolate reductase inhibition, DNA and protein binding properties.

Quinazolinone-benzimidazole conjugates show significant dihydrofolate reductase inhibitory activity and strong DNA and protein binding properties, offering potential for future drug development.

2017·18citations·P. Singla et al.·Journal of photochemistry and photobiology. B, Biology

Journal of photochemistry and photobiology. B, Biology

DOI: 10.1021/ACS.ORGLETT.6B02902

Thio-bisnaphthalimides as Heavy-Atom-Free Photosensitizers with Efficient Singlet Oxygen Generation and Large Stokes Shifts: Synthesis and Properties.

Thio-bisnaphthalimides show high molar absorptivity and large Stokes shifts, making them promising heavy-atom-free photosensitizers for singlet oxygen applications.

2016·24citations·Lei Zhang et al.·Organic letters

Organic letters