Synthesis, antitumour activity and structure-activity relationships of 5H-benzo[b]carbazoles.

doi:10.1016/J.BMC.2004.10.038

Paper

Synthesis, antitumour activity and structure-activity relationships of 5H-benzo[b]carbazoles.

Published Feb 1, 2005 · C. Asche, W. Frank, A. Albert

Bioorganic & medicinal chemistry

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58

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Abstract

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In Vitro Study

Study Snapshot

Novel 5H-benzo[b]carbazoles show promising antitumor activity, with a quinonoid substructure in ring C and 2-hydroxyl substituents increasing activity, suggesting a novel mechanism of action.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis, antitumour activity and structure-activity relationships of 5H-benzo[b]carbazoles.

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