Ethyl 1-aryl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylates 2 were prepared by the condensation of arylhydrazines with ethyl 3-ethoxy-2-(trifluoroacetyl)-2-propenoate (1a) at low temperature. The corresponding acids were also synthesized. X-ray diffraction analysis of an amide derivative 4 verified the position of the trifluoromethyl group on the pyrazole ring.

This study successfully synthesized 1-aryl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acids and esters by condensation of arylhydrazines with ethyl 3-ethoxy-2-(trifluoroacetyl)-2-propen

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Synthesis of 1-aryl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acids and esters

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