Synthesis and bioactivities of novel 4,5,6,7-tetrahydrothieno[2,3-c]pyridines as inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.

Paper

Synthesis and bioactivities of novel 4,5,6,7-tetrahydrothieno[2,3-c]pyridines as inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.

Published 2002 · Masakazu Fujita, T. Seki, H. Inada

Bioorganic & medicinal chemistry letters

Q2 SJR score

3

Citations

1

Influential Citations

Semantic Scholar

Abstract

Novel 4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives were synthesized and evaluated for their abilities to inhibit lipopolysaccharide (LPS)-stimulated production of TNF-alpha in rat whole blood. Several of these compounds exhibited potent inhibitory activity.

Study Snapshot

Novel 4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives show potent inhibitory activity against TNF-alpha production in rat whole blood, offering potential therapeutic applications.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Synthesis and bioactivities of novel 4,5,6,7-tetrahydrothieno[2,3-c]pyridines as inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.

Sign up to use Study Snapshot

References

Citations

Novel pyrrolo[2,3-d]pyrimidines and pyrrolo[2,3-b]pyridines: design, synthesis, and in vivo TNF-α inhibitory activity

Novel pyrrolo[2,3-d]pyrimidines show better TNF- inhibitory activity than pyrrolo[2,3-b]pyridines, with pyrrolopyrimidine 5h showing the most potent activity.

The Gewald multicomponent reaction

The Gewald reaction produces highly substituted 2-aminothiophene derivatives, useful in pharmaceutical industry as small molecular weight inhibitors.

Potential new drugs for therapy of chronic obstructive pulmonary disease

New potential drugs targeting inflammation may improve lung function and reduce airway inflammation in chronic obstructive pulmonary disease patients.