Paper
Synthesis and Bioactivity of Hydrazide-Hydrazones with the 1-Adamantyl-Carbonyl Moiety
Published Nov 1, 2019 · V. H. Pham, Thi Phuong Dung Phan, Dinh Chau Phan
Molecules
Q1 SJR score
19
Citations
1
Influential Citations
Abstract
Reaction of 1-adamantyl carbohydrazide (1) with various substituted benzaldehydes and acetophenones yielded the corresponding hydrazide-hydrazones with a 1-adamantane carbonyl moiety. The new synthesized compounds were tested for activities against some Gram-negative and Gram-positive bacteria, and the fungus Candida albicans. Compounds 4a, 4b, 5a, and 5c displayed potential antibacterial activity against tested Gram-positive bacteria and C. albicans, while compounds 4e and 5e possessed cytotoxicity against tested human cancer cell lines.
In Vitro StudyStudy Snapshot
Hydrazide-hydrazones with 1-adamantane carbonyl moiety show potential antibacterial activity against Gram-positive bacteria and Candida albicans, and cytotoxicity against human cancer cell lines.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
5-Adamantan thiadiazole-based thiazolidinones as antimicrobial agents. Design, synthesis, molecular docking and evaluation.
Compound 8 shows the best antibacterial potential against ATCC and resistant strains, while also showing antifungal activity better than bifonazole and ketokonazole.
2018·57citations·M. Fesatidou et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry
Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic studies.
BCHHD 11b shows excellent anticancer activity against pancreatic carcinoma, hepatocellular carcinoma, and leukemia cell lines, and may serve as a promising radiopharmaceutical imaging agent for cancer.
2018·61citations·T. Nasr et al.·European journal of medicinal chemistry
European journal of medicinal chemistry
Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities.
Novel adamantyl and noradamantyl phthalimidines show neuroprotective and anti-angiogenic properties, with nitrite reduction and TNF- inhibition.
2018·15citations·Weiming Luo et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry
Synthesis and investigation of antimicrobial activities of nitrofurazone analogues containing hydrazide-hydrazone moiety
Nitrofurazone analogues show high bactericidal effects against Staphylococcus spp. ATTC and Bacillus spp. ATTC, with some showing better activity than nitrofurantoin, ciprofloxacin, or cefuroxime.
2017·49citations·Łukasz Popiołek et al.·Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal : SPJ
Adamantane-Isothiourea Hybrid Derivatives: Synthesis, Characterization, In Vitro Antimicrobial, and In Vivo Hypoglycemic Activities
Adamantane-isothiourea hybrid derivatives show potent antimicrobial activity and in vivo hypoglycemic activity, with compounds 7a, 8ab, and 8b showing dose-independent reduction of serum glucose levels in diabetic rats.
2017·41citations·L. Al-Wahaibi et al.·Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
New Adamantyl Chalcones: Synthesis, Antimicrobial and Anticancer Activities.
New adamantyl chalcones show strong antibacterial and anticancer activity against human pancreas cancer cell MiaPaca2, suggesting potential as antimicrobial agents.
2016·10citations·Aouatef Tabbi et al.·Current topics in medicinal chemistry
Current topics in medicinal chemistry
Synthesis, antitumor activity and mechanism of action of novel 1,3-thiazole derivatives containing hydrazide-hydrazone and carboxamide moiety.
Novel 1,3-thiazole derivatives with hydrazide-hydrazone and carboxamide moiety show promising antitumor activity against various human cancer cell lines, with T1 and T38 inducing apoptosis through S cell-cycle arrest.
2016·65citations·Haifeng He et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
Synthesis, crystal structure, superoxide scavenging activity, anticancer and docking studies of novel adamantyl nitroxide derivatives
Novel adamantyl nitroxide derivatives show stronger antioxidant and anticancer activity, with potential for use in EGFR binding sites.
2016·13citations·Xiaohe Zhu et al.·Journal of Molecular Structure
Journal of Molecular Structure
Synthesis and antituberculosis activity of indole-pyridine derived hydrazides, hydrazide-hydrazones, and thiosemicarbazones.
Novel indole-pyridine hydrazides and hydrazide-hydrazones show in vitro antituberculosis activity, warranting further in vivo studies.
2016·79citations·V. Velezheva et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
Citations
Novel Adamantane Derivatives: Synthesis, Cytotoxicity and Antimicrobial Properties
Four novel adamantane derivatives showed the highest antibacterial potential, with no significant cytotoxicity observed at tested doses.
2024·1citation·Łukasz Popiołek et al.·Applied Sciences
Applied Sciences
New 2H‐Chromene‐Based Hydrazone Derivatives as Promising Anti‐Breast Cancer Agents: Efficient Synthesis, Spectral Characterization, Molecular Docking, and ADMET Studies
New 2H-chromene-based hydrazone derivatives show promising anti-breast cancer activity, with compounds 10 r and 12 b showing the most potent antiproliferative effects against MCF-7 breast cancer cells.
2024·2citations·Bhabani Shankar Panda et al.·ChemistrySelect
ChemistrySelect
Nascent pharmacological advancement in adamantane derivatives
Adamantane derivatives show potential in drug development and discovery due to their enhanced absorption, metabolism, and excretion properties when combined with other pharmacophoric moieties.
2023·9citations·Aman Ragshaniya et al.·Archiv der Pharmazie
Archiv der Pharmazie
Novel N-Acyl Hydrazone Compounds as Promising Anticancer Agents: Synthesis and Molecular Docking Studies
Novel N-acyl hydrazone compounds 7a-e, 8a-e, and 9a-e show promising anticancer activity against breast and prostate cancer cells without harming normal cells.
2023·19citations·Yağmur Biliz et al.·ACS Omega
ACS Omega
Synthesis, Structure-Activity Relationship, and Mechanism of a Series of Diarylhydrazide Compounds as Potential Antifungal Agents.
Diarylhydrazide 2c shows potential as a potent antifungal agent against phytopathogenic diseases, with excellent activity against Alternaria brassicae and other plant pathogens.
2023·14citations·Ruiyuan Liu et al.·Journal of agricultural and food chemistry
Journal of agricultural and food chemistry
Synthesis and Pharmacological Profile of Hydrazide Compounds
Hydrazide compounds have significant medical, pharmaceutical, and industrial applications, including treating respiratory diseases, malaria, and chronic blood vessel and muscle spasms, and preparing heterocyclic compounds for dyes, pesticides, and plant growth stimulants.
2023·6citations·Ghufran Th. Sadeek et al.·Research Journal of Pharmacy and Technology
Research Journal of Pharmacy and Technology
Identification of novel diclofenac acid and naproxen bearing hydrazones as 15-LOX inhibitors: Design, Synthesis, In vitro evaluation, cytotoxicity, and In silico studies
Novel diclofenac acid and naproxen-bearing hydrazones show potential as 15-LOX inhibitors, with the most potent compounds showing least cytotoxicity and drug-likeness.
2022·7citations·A. Sardar et al.·Arabian Journal of Chemistry
Arabian Journal of Chemistry
Spectroscopic, Solvation Effects and MD Simulation of an Adamantane-Carbohydrazide Derivative, a Potential Antiviral Agent
DMC, a potential antiviral agent, shows good contacts with protein binding site residues, indicating antiviral activity.
2022·7citations·L. Al-Wahaibi et al.·Polycyclic Aromatic Compounds
Polycyclic Aromatic Compounds
Inhibitory Potential of New Phenolic Hydrazide-Hydrazones with a Decoy Substrate Fragment towards Laccase from a Phytopathogenic Fungus: SAR and Molecular Docking Studies
New phenolic hydrazide-hydrazones with a decoy substrate fragment show strong inhibitory potential against laccase from phytopathogenic fungi, offering potential for new antifungal agents in plant cultivation, gardening, and horticulture.
2021·9citations·H. Maniak et al.·International Journal of Molecular Sciences
International Journal of Molecular Sciences