Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline

doi:10.25026/JTPC.V4I4.183

Paper

Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline

Published Dec 31, 2018 · Nurul Khotimah, Agung Rahmadani, Dewi Rahmawati

Journal of Tropical Pharmacy and Chemistry

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Abstract

Pyrazoline is a five-ring heterocyclic compound having 3 carbon atoms and 2 nitrogen atoms known to have some biological activity. This study aims to synthesize 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) pyrazoline using 2â€™,4â€™-dichloro-4-hydroxy-3-methoxy chalcone and hydrazine. Synthesis was performed by reflux method at 80oC for 7 hours. The synthesis compounds were characterized by structural elucidation techniques. From the synthesis results obtained compound 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) Pyrazoline is pale yellow powder with 84%yield. The result of antioxidant activity test by 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that the compound had very strong antioxidant activity, Antibacterial test by diffusion method to use paper disk showed that the compound had antibacterial activity against Gram positive bacteria (S.aureus) and Gram negative bacteria (E.coli) and toxicity test by Brine Shrimp Lethality Test (BSLT) showed that the compound had toxicity.

Study Snapshot

3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) pyrazoline shows strong antioxidant activity, antibacterial activity against Gram positive and Gram negative bacteria, and toxicity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline

References

SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA ANALOG PIRAZOLIN TURUNAN 3’BROMOKALKON INTI NAFTALEN

The synthesized pyrazoline analog compound PP2 shows low antibacterial activity, but its inhibition against Gram-positive bacteria is greater than that of Gram-negative bacteria.

Synthesis And Anticonvulsant Activity Of Some Substituted 3,5-Diphenyl-2-Pyrazoline-1-Carboxamide Derivatives

Substituted 3,5-diphenyl-2-pyrazoline-1-carboxamide derivatives show anticonvulsant activity, with compounds 4d-4e, 4j-4k, and 4m-4t being most protective against maximal electroshock seizure at 30 mg/kg dose levels.

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