Synthesis and Biological Activities of Novel 1,3,4-Thiadiazole Amide Derivatives Containing Piperazine

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Synthesis and Biological Activities of Novel 1,3,4-Thiadiazole Amide Derivatives Containing Piperazine

Published 2015 · Z. Xia

Chinese Journal of Synthetic Chemistry

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Abstract

Fifteen novel 1,3,4-thiadiazole amide compounds containing piperazine were synthesized using aminothiourea and carbon disulfide as the starting materials. The structures were characterized by1 H NMR,13 C NMR,IR,ESI-MS and elemental analysis. The bioassay results indicated that N-{ 5-[( 2,4-dichlorobenzyl) thio]-1,3,4-thiadiazol-2-yl}-2-( 4-methylpiperazin-1-yl) acetamide( 6b)and N-【5-{ [4-( trifluoromethoxy) benzyl]thio }-1,3,4-thiadiazol-2-yl 】-2-( 4-methylpiperazin-1-yl)acetamide( 6e) demonstrated inhibitory effects on Xan-thomonas campestris pv. oryzae with EC50of17. 5 μg·m L-1and 19. 8 μg · m L-1,respectively. N-{ 5-[( 3-methylbenzyl) thio]-1,3,4-thiadiazol-2-yl}-2-( piperazin-1-yl) acetamide( 6k) showed certain antiviral activity against tobacco mosaic virus at 500 μg·m L-1.

In Vitro Study

Study Snapshot

Novel 1,3,4-thiadiazole amide compounds containing piperazine show inhibitory effects on Xanthomonas campestris pv. oryzae and antiviral activity against tobacco mosaic virus.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and Biological Activities of Novel 1,3,4-Thiadiazole Amide Derivatives Containing Piperazine

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