Synthesis And Biological Activity Of 2-(3â€™, 5â€™, -Dibromo-2â€™-Hydroxypheny)-3-Aryl-5H/Methyl/Carboxymethyl-4-Thiazolidinones

Paper

Synthesis And Biological Activity Of 2-(3â€™, 5â€™, -Dibromo-2â€™-Hydroxypheny)-3-Aryl-5H/Methyl/Carboxymethyl-4-Thiazolidinones

Published Sep 1, 2002 · A. Bapodra, F. Bharmal, Hansa Parekh

Indian Journal of Pharmaceutical Sciences

Q3 SJR score

7

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0

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Abstract

With a view to map out the synthesis and antimicrobial activity of series of 2-(3',5'-dibromo-2'- hydroxyphenyI)-3-aryl-5H/methyl/carboxymethyl-4-thiazolidinones (Ill-a-ss) have been prepared by the cyclocondensation of N-substituted-(3,5-dibromo-2-hydroxy benzylidene)-anilines (ll) with a-substituted mercaptoacetic acids and evaluated for their in vitro growth inhibiting activity against several microbes. Some of the compounds show significant antimicrobial activity.

Study Snapshot

2-(3',5'-dibromo-2'-hydroxypheny)-3-aryl-5H/methyl/carboxymethyl-4-thiazolidinones show significant antimicrobial activity against various microbes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Synthesis And Biological Activity Of 2-(3â€™, 5â€™, -Dibromo-2â€™-Hydroxypheny)-3-Aryl-5H/Methyl/Carboxymethyl-4-Thiazolidinones

References

Citations

Testing the ability of rhodanine and 2, 4-thiazolidinedione to interact with the human pancreatic alpha-amylase: electron-density descriptors complement molecular docking, QM, and QM/MM dynamics calculations

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A Simple Approach to the Synthesis of 3-Substituted Rhodanines and Thiazolidine-2,4-diones

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Compound 4a shows fungicidal activity and selective activity against Cryptococcus neoformans and dermatophytes, with MIC ranges between 2 and 16 g/mL.

Rhodanine Derivatives as Selective Protease Inhibitors Against Bacterial Toxins

Rhodanine derivatives show potential as selective protease inhibitors against anthrax and botulinum bacterial toxins, offering a framework for developing potential drug candidates against these diseases.