Synthesis and Biological Activity of 3-Aryl-5-(3′-bromo/chlorophenyl)isoxazoles.

doi:10.1002/CHIN.200437125

Paper

Synthesis and Biological Activity of 3-Aryl-5-(3′-bromo/chlorophenyl)isoxazoles.

Published Sep 14, 2004 · K. Popat, K. Nimavat, V. Kachhadia

ChemInform

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Abstract

3-Aryl-5-(3'-bromo/chlorophenyl)isoxazole derivatives (3a-j, 4a-j) have been prepared by condensing I-aryl-3-(3'-bromo/ chlorophenyl)-2-propen-1-ones (1a-j, 2a-j) with hydroxylamine hydrochloride. Compounds la-j, 2a-j have been synthesized by the reaction of 3-bromobenzaldehyde with different aryl methyl ketones. All the compounds are screened for their antitubercular and antimicrobial activities.

Study Snapshot

3-Aryl-5-(3'-bromo/chlorophenyl)isoxazole derivatives show promising antitubercular and antimicrobial activities.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and Biological Activity of 3-Aryl-5-(3′-bromo/chlorophenyl)isoxazoles.

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