Paper
Synthesis of carbon‐14 labeled 1‐(4‐methoxybenzoyl)‐5‐oxo‐2‐pyrrolidinepropanoic acid (CI‐933)
Published Jun 1, 1987 · C. C. Huang
Journal of Labelled Compounds and Radiopharmaceuticals
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13
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0
Influential Citations
Abstract
1-(4-Methoxybenzoyl)-5-oxo-2-pyrrolidinepropanoic acid (CI-933) (17), a new cognition activating agent, was radiolabeled with carbon-14. The synthesis was accomplished using bromo[1-14C]acetic acid as the starting material. A facile one-pot synthesis of an α,β-unsaturated ester 10 from an alcohol 2 and a Wittig reagent 15 in the presence of Dess-Martin periodinane was developed.
Study Snapshot
Carbon-14-labeled 1-(4-methoxybenzoyl)-5-oxo-2-pyrrolidinepropanoic acid (CI-933) (17) is a new cognition activating agent, which can be synthesized in a one-pot process using bromo[1-14
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Synthesis of 14C‐ and 3H‐labeled CI‐911 (dihydro‐1H‐pyrrolizine‐3, 5 (2H, 6H)‐dione)
CI-911, a new cognition activating agent, was synthesized with radiochemical yields of 9.2% and 28.1 Ci/mmol, demonstrating its potential as a new drug target.
1985·5citations·Jon D. Hartman et al.·Journal of Labelled Compounds and Radiopharmaceuticals
Journal of Labelled Compounds and Radiopharmaceuticals
Amnesia-reversal activity of a series of N-[(disubstituted-amino)alkyl] -2-oxo-1-pyrrolidineacetamides, including pramiracetam.
Pramiracetam, a neuroprotective agent, shows promising amnesia-reversal activity and is well-tolerated in normal human volunteers.
1984·42citations·D. Butler et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Synthesis of 14C-labeled pramiracetam hydrochloride, N-[2-(bis[1-methylethyl]amino)ethyl]-2-oxo-1-pyrrolidine-acetamide-α-14C hydrochloride, CI-879 hydrochloride
Pramiracetam hydrochloride, a potential clinically useful cognition activator, was successfully synthesized using 14C-labeled bromoacetic-2-14C acid and N,N-bis(1-methylethyl)-1,2-ethanediamine.
1984·5citations·Jon D. Hartman et al.·Journal of Labelled Compounds and Radiopharmaceuticals
Journal of Labelled Compounds and Radiopharmaceuticals
Citations
Recent developments in one-pot tandem oxidation process coupling reactions
The tandem oxidation process (TOP) has evolved to produce useful compounds using novel oxidants, catalysts, and reaction conditions, enabling multicomponent reactions and total syntheses.
2014·28citations·V. Jeena et al.·RSC Advances
RSC Advances
Tandem oxidative processes catalyzed by polymer-incarcerated multimetallic nanoclusters with molecular oxygen.
Polymer-incarcerated multimetallic nanoclusters can efficiently catalyze one-pot tandem oxidative processes using molecular oxygen, enabling efficient organic syntheses and green chemistry.
2014·77citations·H. Miyamura et al.·Accounts of chemical research
Accounts of chemical research
A heterogeneous layered bifunctional catalyst for the integration of aerobic oxidation and asymmetric C-C bond formation.
The heterogeneous bifunctional catalyst effectively integrates aerobic oxidation and asymmetric C-C bond formation, with layering bimetallic nanoparticles over the organocatalyst being crucial for catalytic activity.
2013·38citations·H. Miyamura et al.·Chemical communications
Chemical communications
(±) trans‐3,3′‐(1,2‐Cyclopropanediyl)Bis‐2‐(E)‐Propenoic Acid, Diethyl Ester : Tandem Oxidation Procedure (Top) Using MnO2 Oxidation‐Stabilized Phosphorane Trapping
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2008·2citations·R. Taylor et al.·Organic Syntheses
Organic Syntheses
IBX-mediated oxidative Ugi-type multicomponent reactions: application to the N and C1 functionalization of tetrahydroisoquinoline.
Iodoxybenzoic acid (IBX) effectively mediates oxidative Ugi-type multicomponent reactions, enabling the N and C1 functionalization of tetrahydroisoquinoline in good to excellent yields.
2007·135citations·Tifelle Ngouansavanh et al.·Angewandte Chemie
Angewandte Chemie
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2007·17citations·Y. Makhynya et al.·European Journal of Organic Chemistry
European Journal of Organic Chemistry
Alcohols in isonitrile-based multicomponent reaction: Passerini reaction of alcohols in the presence of o-iodoxybenzoic acid.
An alc. can effectively partner with an aldehyde in the Passerini reaction, leading to alpha-acyloxy carboxamides in good to excellent yields.
2006·76citations·Tifelle Ngouansavanh et al.·Angewandte Chemie
Angewandte Chemie
DMP-mediated one-pot oxidative olefination of silyl ethers
This study demonstrates a one-pot oxidative olefination method for silyl ethers, achieving high selectivity and high efficiency, with good to excellent yields.
2005·12citations·Guisheng Deng et al.·Tetrahedron
Tetrahedron
IN SITU ALCOHOL OXIDATION-WITTIG REACTIONS
Oxidizing alcohols with manganese dioxide and Wittig reagents can generate,-unsaturated esters, making it useful for difficult-to-isolate intermediate aldehydes.
1998·77citations·Xudong Wei et al.·Tetrahedron Letters
Tetrahedron Letters