Synthesis and characterization of 4-((5-bromo-1H-pyrazolo [3,4-b]pyridin-3-yl)amino)-N-(substituted)benzenesulfonamide as Antibacterial, and Antioxidant Candidates

doi:10.5267/j.ccl.2019.5.001

Paper

Synthesis and characterization of 4-((5-bromo-1H-pyrazolo [3,4-b]pyridin-3-yl)amino)-N-(substituted)benzenesulfonamide as Antibacterial, and Antioxidant Candidates

Published 2019 · Hiren H. Variya, V. Panchal, G. Patel

Current Chemistry Letters

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Abstract

Article history: Received May 8, 2019 Received in revised form May 12, 2019 Accepted May 28, 2019 Available online May 28, 2019 A series of novel 5-Bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine linked various sulfonamide derivatives 8a-8j poly functionalized were designed and synthesized in moderate to good yield. A starting with iodination of 5-Bromo-1H-pyrazolo[3,4-b]pyridine 5 with iodine produced intermediate 5-Bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine 6 with the reaction of various sulfonamide derivatives 7a-7j via copper catalyzed coupling reaction produced targeted compounds8a-8j. The isolated compounds were accepted by spectral and elemental analysis. The compounds 8a,8c,8d, and 8i were excellent active against Gram-positive and gram-negative bacterial strain compare to streptomycin standard drug. All synthesized compounds showed moderate to good antioxidant properties with used DPPH and Superoxide radical scavenging assay, Compounds 8c, 8g, and 8i exerted significant antioxidant scavenging activity for the DPPH radical. © 2019 by the authors; licensee Growing Science, Canada.

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Novel compounds synthesized from 5-Bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine show excellent antibacterial and antioxidant properties, with compounds 8c, 8g, and 8i showing significant DPPH radical scavenging activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and characterization of 4-((5-bromo-1H-pyrazolo [3,4-b]pyridin-3-yl)amino)-N-(substituted)benzenesulfonamide as Antibacterial, and Antioxidant Candidates

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References

Design of new metal complexes of 2-(3-amino-4,6-dimethyl-1H-pyrazolo[3,4-b]pyridin-1-yl)aceto-hydrazide: Synthesis, characterization, modelling and antioxidant activity

The Cu(II) complex of 2-(3-amino-4,6-dimethyl-1H-pyrazolo[3,4-b]pyridin-1-yl)aceto-hydrazide shows higher antioxidant activity than other complexes, improving the activity of the ligand.

Novel chloroquinoline derivatives incorporating biologically active benzenesulfonamide moiety: synthesis, cytotoxic activity and molecular docking

Novel chloroquinoline derivatives incorporating benzene-sulfonamide moiety show promising anticancer activity, with potential mechanisms of action through inhibition of PI3K enzyme.

Design, synthesis and biological evaluation of 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine derivatives as c-Met inhibitors.

Novel 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine derivatives show potential as strong c-Met inhibitors and moderate ALK inhibitors, with compound 9 showing strong cell inhibition.

Design, synthesis, antimicrobial evaluation and molecular docking studies of some new 2,3-dihydrothiazoles and 4-thiazolidinones containing sulfisoxazole

New compounds containing sulfisoxazole show potential as potent antimicrobial agents against various bacteria, potentially offering a platform for future drug design.

Novel benzothiazole containing 4H-pyrimido[2,1-b]benzothiazoles derivatives: One pot, solvent-free microwave assisted synthesis and their biological evaluation

This study presents a one-pot, solvent-free microwave assisted synthesis of novel benzothiazole derivatives with potential antibacterial, antioxidant, and antitubercular activities.

Citations

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